ПАТОГЕНЕТИЧНІ ВЗАЄМОЗВ’ЯЗКИ ЕКОГЕНЕТИЧНИХ ЧИННИКІВ У ФОРМУВАННІ БРОНХІАЛЬНОЇ АСТМИ В ДІТЕЙ
DOI:
https://doi.org/10.24061/1727-4338.XII.1.43.2013.49Ключові слова:
бронхіальна астма, діти, ацетиляторний фенотип, екологічні чинникиАнотація
На підставі аналізу даних наукових першоджерел, обговорені можливі патогенетичні паралелі та взаємозв 'язки генетичних (зокрема, активності ацетиляторних процесів і генетичного поліморфізму гену N-ацетилтрансферази) та екологічних чинників у формуванні гіперреактивності дихальних шляхів та фенотипу бронхіальної астми в дітей. Показані сучасні наукові тенденції, зроблено акценти на суперечливих моментах.Посилання
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Ohshima Y, Yamada A, Hiraoka M, KatamuraK, Ito S, HiraoT, et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4-year followup study. Ann Allergy Asthma Immunol. 2002;89(3):265-70. doi:10.1016/S1081-1206(10)61953-9.
Kim JJ, American Academy of Pediatrics Committee on Environmental Health. Ambient Air Pollution: Health Hazards to Children. 2004;114(6):1699-707. doi: 10.1542/peds.2004-2166.
D’Amato G, Liccardi G, D’Amato M, HolgateS. Environmental risk factor and allergic bronchial asthma. Clin Exp Allergy. 2005;35(9):1113-24. doi: 10.1111/j.1365-2222.2005.02328.x.
Delacourt C. [Skin tests for trophallergens and asthma]. Allerg Immunol (Paris). 2002;34(10):375-6.
Dietert RR, Etzel RA, Chen D, HalonenM, HolladaySD, JarabekAM, et al. Workshop to identifity critical windows of exposure for children’s health: immune and respiratory systems work group summary. Environ Health Perspect. 2000;108(Suppl 3):483-90. doi: 10.1289/ehp.00108s3483.
Ehlenfield DR, Cameron K, Welliver RC. Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease. Pediatrics. 2000;105(1 Pt 1):79-83. doi: 10.1542/peds.105.1.79
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Gavett SH, Haykal-Coates N, Copeland LB, HeinrichJ, Gilmour MI. Metal composition of ambient PM2.5 influences severity of allergic airways disease in mice. Environ Health Perspect. 2003;111(12):1471-7. doi: 10.1289/ehp.6300.
Gergen PJ. Environmental tobacco smoke as a risk factor for respiratory disease in children. Respir Physiol. 2001;128(1):39-46. doi:https://doi.org/10.1016/S0034-5687(01)00263-8" target="_blank">10.1016/S0034-5687(01)00263-8.
Grant DM, GoodfellowGH, SugamoriK, Durette K. Pharmacogenetics of the human arylamine N-acetyltransferases. 2000;61(3):204-11. doi: 10.1159/000028402
HeinDW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH, et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer EpidemВiomars and Preven. 2000;9(1):29-42.
Holgate ST, Lack G. Improving the management of atopic disease. Arch Dis Child. 2005;90(8):826-31. doi:10.1136/adc.2004.053280
Jaakkola JJK. Case-crossover desing in air pollution epidemiology.Eurо Respir J. 2003;21(40):81s-5s. doi: 10.1183/09031936.03.00402703
Karila C. Allergen skin tests. Asthmatic infants and young children. Arch Pediatr. 2002;9(Suppl 3):338s-343s. doi:https://doi.org/10.1016/S0929-693X(02)00140-9" target="_blank">10.1016/S0929-693X(02)00140-9
Kauffmann F, Post Genome Respiratory Epidemiology Group. Post-genome respiratory epidemiology: a multidisciplinary challenge. Eur Respir J. 2004;24(3):471-80. doi: 10.1183/09031936.04.00076803.
Kilpelainen M, Terho EO, Helenius H, KoskenvuoM. Childhood farm environment and asthma and sensitization in young adulthood. Allergy. 2002;57(12):1130-5. doi: 10.1034/j.1398-9995.2002.23341.x.
Lemanske RF. Origins and treatment of airway inflammation in childhood asthma.Merck Pediatric Respiratory Specialists Consultants’ Meeting. Challenges in Pediatric Asthma Manageme; 1999 Aug 26-29; Seattle, Wash. PediatPulmonol. 2001;21:17-25.
Liccardi G, D’Amato G, Canonica GW, SalzilloA, PiccoloA, PassalacquaG. Systemic reaction from skin testing: literature review. J InvestigAllergol Clin Immunol. 2006;16(2):75-8.
Liu L, Jarjour NN, Busse WW, Kelly EAB. Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am J Respir Crit Care Med. 2004;169(10):1118-24. doi: 10.1164/rccm.200312-1659OC.
London SJ, Gauderman WJ, Avol E, RappaportEB, PetersJM. Family history and the risk of early-onset persistent, early-onset transient, and late-onset asthma. Epidemiology. 2001;12(5):577-83. doi:10.1097/00001648-200109000-00019
Mead MN. Environmental roots of asthma. Environ Health Perspect. 2005 Jan;113(1):A32-3. doi: 10.1289/ehp.113-a32.
Nacak M, Aynacioglu AS, Filiz A, CascorbiI, ErdalME, YilmazN, et al. Association between the N-acetylation genetic polimorphism and bronchial asthma. Br J Clin Pharmacol. 2002;54(6):671-4. doi:10.1046/j.1365-2125.2002.01670.x.
Ohshima Y, Yamada A, Hiraoka M, KatamuraK, Ito S, HiraoT, et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: results of a 4-year followup study. Ann Allergy Asthma Immunol. 2002 Sep;89(3):265-70. doi:10.1016/S1081-1206(10)61953-9.
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