БАГАТОРІЧНИЙ ДОСВІД РОБОТИ КАФЕДРИ ПЕДІАТРІЇ ТА ДИТЯЧИХ ІНФЕКЦІЙНИХ ХВОРОБ ПО ОПТИМІЗАЦІЇ МЕНЕДЖМЕНТУ ТА ПРОФІЛАКТИКИ БРОНХІАЛЬНОЇ АСТМИ У ДІТЕЙ З ПОЗИЦІЙ ЇЇ ФЕНОТИПОВОЇ НЕОДНОРІДНОСТІ
DOI:
https://doi.org/10.24061/1727-4338.XVI.1.59.2017.1Ключові слова:
діти, бронхіальна астма, профілактика, фенотипова неоднорідністьАнотація
Огляд наукових досліджень, виконаних колективом кафедри педіатрії та дитячих інфекційних хвороб упродовж останнього десятиліття в напрямку вивчення фенотипової неоднорідності бронхіальної астми у дітей. Наводяться конкретні досягнення і наукові висновки, які є пріоритетними та значно випередили розвиток сучасних поглядів на неоднорідність захворювання. Науковий доробок кафедри представлено захищеними 3 докторськими та 16 кандидатськими дисертаціями, 1 дисертацією на етапі апробації; 1 методичними рекомендаціями МОЗ України, 9 інформаційними листами, 7 нововведеннями в Галузевому реєстрі, 34 патентами України на корисну модель, 69 раціоналізаторськими пропозиціями. За даний період надруковано 1654 роботи з вказаної наукової проблематики.Посилання
Hryhola OH. Bronkhial'na astma fizychnoi napruhy v shkoliariv (chynnyky skhyl'nosti, klinichno-paraklinichni osoblyvosti perebihu, diahnostyka, obgruntuvannia likuval'nykh zakhodiv) [Bronchial asthma of physical stress in schoolchildren (predisposing factors, clinical-paraclinical peculiarities of the course, diagnosis, substantiation of therapeutic measures)] [avtoreferat]. Chernivtsi; 2015. 23 s. (in Ukrainian).
Vorotniak TM. Vdoskonalennia likuvannia ditei, khvorykh na bronkhial'nu astmu, zalezhno vid aktyvnosti khronichnoho zapalennia bronkhiv [Improving the treatment of children with bronchial asthma, depending on the activity of chronic bronchial inflammation] [avtoreferat]. Odesa; 2009. 20 s. (in Ukrainian).
Ivanova LA. Henotypichno-klinichne prohnozuvannia fenotypiv bronkhial'noi astmy u ditei [Genotypic-clinical prediction of the phenotypes of bronchial asthma in children] [avtoreferat]. Odesa; 2013. 36 s. (in Ukrainian).
Geppe NA, Revyakina VA. Novye mezhdunarodnye rekomendatsii po bronkhial'noy astme u detey PRACTALL [New international recommendations for bronchial asthma in children PRACTALL]. Atmosfera. Pul'monologiya i allergologiya. 2008;(1):60-7. (in Russian)
Shakhova OO. Diahnostychna tsinnist' pokaznykiv nespetsyfichnoi reaktyvnosti bronkhiv pry bronkhial'nii astmi u pidlitkiv [Diagnostic value of indicators of nonspecific bronchial reactivity in bronchial asthma in adolescents] [avtoreferat]. Chernivtsi; 2013. 20 s. (in Ukrainian).
Mykaliuk LV. Efektyvnist' likuvannia bronkhial'noi astmy u ditei za alel'noho polimorfizmu heniv GSTT1, GSTM1 [Effectiveness of treatment of bronchial asthma in children for allelic polymorphism of genes GSTT1, GSTM1] [avtoreferat]. Chernivtsi; 2014. 23 s. (in Ukrainian).
Koloskova OK, Tarnavs'ka SI. Zapal'ni paterny krovi yak oznaka fenotypovoi neodnoridnosti bronkhial'noi astmy u ditei (ohliad literatury) [Inflammatory blood patterns as a sign of phenotypic heterogeneity of bronchial asthma in children (review of literature)]. Sovremennaya pediatriya. 2016;(1):116-9. (in Ukrainian).
Prunchak SI. Kliniko-imunolohichna kharakterystyka bronkhial'noi astmy v ditei z riznymy typamy atsetyliuvannia [Clinical and immunological characteristics of bronchial asthma in children with different types of acetylation] [avtoreferat]. L'viv; 2007. 20 s. (in Ukrainian).
Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry bronkhial'nii astmi [On Approval and Implementation of Medical-Technological Documents on Standardization of Medical Aid in Bronchial Asthma]. Nakaz MOZ Ukrainy vid 08.10.2013. № 868. Kyiv: MOZ Ukrainy, 2013. (in Ukrainian).
Azhimi Mukhamed Sof'ien Ben Ali. Nespetsyfichna reaktyvnist' bronkhiv na foni medykamentoznoho likuvannia ditei z bronkhial'noiu astmoiu [Non-specific bronchial reactivity against the background of medical treatment for children with bronchial asthma] [avtoreferat]. Odesa; 2006. 20 s. (in Ukrainian).
Ortemenka YeP. Obgruntuvannia dyferentsiiovanoho likuvannia bronkhial'noi astmy u ditei zalezhno vid typu zapalennia dykhal'nykh shliakhiv [Substantiation of differentiated treatment of bronchial asthma in children depending on the type of airway inflammation] [avtoreferat]. Odesa; 2009. 20 c. (in Ukrainian).
Yurchyshena EV. Osoblyvosti perebihu bronkhial'noi astmy u ditei z kharchovoiu alerhiieiu [Features of the course of bronchial asthma in children with food allergy] [avtoreferat]. Odesa; 2004. 20 s. (in Ukrainian).
Haluschyns'ka AV. Prohnozuvannia kharakteru zapalennia dykhal'nykh shliakhiv u ditei, khvorykh na bronkhial'nu astmu, pry polimorfizmi heniv GSTTI, GSTMI ta eNOS [Prediction of the nature of respiratory inflammation in children with bronchial asthma, with GSTTI, GSTMI and eNOS germ polymorphism] [avtoreferat]. Ivano-Frankivs'k; 2014. 20 s. (in Ukrainian).
Bezrukova TL. Prohnostychni kryterii ryzyku retsydyviv bronkhoobstruktyvnoho syndromu u ditei rann'oho viku [Prognostic criteria for the risk of recurrence of broncho-obstructive syndrome in young children] [avtoreferat]. Kyiv; 2006. 20 s. (in Ukrainian).
Koloskova OK. Stan zdorov`ia ditei, yaki prozhyvaiut' v zonakh poiednanoho zabrudnennia gruntu malymy dozamy solei vazhkykh metaliv ta tekhnohennykh radionuklidiv (kliniko-epidemiolohichnyi analiz, likuvannia, profilaktyka) [The state of health of children living in zones of combined soil pollution with low doses of heavy metal salts and man-made radionuclides (clinical and epidemiological analysis, treatment, prevention)] [avtoreferat]. Odesa; 2006. 38 s. (in Ukrainian).
Haras MN. Tiazhka persystuiucha bronkhial'na astma u ditei shkil'noho viku (diahnostychni kryterii ta likuvannia) [Severe persistent bronchial asthma in schoolchildren (diagnostic criteria and treatment)] [avtoreferat]. Chernivtsi; 2011. 20 s. (in Ukrainian).
Umanets' TR. Kliniko-anamnestychni osoblyvosti fenotypiv bronkhial'noi astmy u ditei [Clinical and anamnestic features of phenotypes of bronchial asthma in children]. Perinatologiya i pediatriya. 2011;(2):69-71. (in Ukrainian).
Selroos O, Löfroos AB, Pietinalho A, Riska H. Asthma control and steroid doses 5 years after early or delayed introduction of inhaled corticosteroids in asthma: a real-life study. Respir Med. 2004 Mar;98(3):254-62.
Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011 Feb;127(2):355-60. doi: 10.1016/j.jaci.2010.11.037.
Asthma prevalence health care use and mortality: United States, 2002 [Internet]. National Center for Health Stastistics; 2003 [updated 2015 Nov 6; cited 2017 Jan 15]. Available from: https://www.cdc.gov/nchs/data/hestat/asthma/asthma.htm
Bloom B, Cohen RA, Freeman G. Summary health statistics for US children: National Health Interview Surway. Vital Health Stat 10. 2010 Dec;(247):1-82.
Bourdin A, Chanez P. Clustering in asthma: why, how and for how long? Eur Respir J. 2013 Jun;41(6):1308-14. doi: 10.1183/09031936.00003313.
Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, Melén E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12 – data from the BAMSE birth cohort. Allergy. 2012;67:537-44. doi: 10.1111/j.1398-9995.2012.02786.x
Expert Panel Report 3 (EPR-3): Guidelines for diagnosis and management of asthma: Summary Report 2007. J Allergy Clin Immunol. 2007;120(5):S94-S138. doi: 10.1016/j.jaci.2007.09.029.
Gaga M, Zervas E, Gibson PG. Allergic and non-allergic factors in severe asthma. Eur Respir Mon. 2011;51:107-19.
Lara M, Rosenbaum S, Rachelefsky G, Nicholas W, Morton SC, Emont S, et al. Improving childhood asthma outcomes in the United States: blueprint for policy action. Pediatrics. 2002 May;109(5):919-30.
National Heart, Lung, and Blood Institute [Internet]. 2006 [updated 2009 Dec; cited 2017 Feb 12]. Available from: https://www.nhlbi.nih.gov/
Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R, et al. International consensus on (ICON) pediatric asthma. Allergy. 2012 Aug;67(8):976-97. doi: 10.1111/j.1398-9995.2012.02865.x.
Bush A, Pedersen S, Hedlin G, Baraldi E, Barbato A, de Benedictis F, et al. Pharmacological treatment of severe, therapy-resistant asthma in children: what can we learn from where? Eur Respir J. 2011 Oct;38(4):947-58. doi: 10.1183/09031936.00030711.
Campo P, Rodríguez F, Sánchez-García S, Barranco P, Quirce S, Pérez-Francés C, et al. Phenotypes and Endotypes of Uncontrolled Severe Asthma: New Treatments. J Investig Allergol Clin Immunol. 2013;23(2):76-88.
Pocket Guide for Asthma Management and Prevention (for Adults and Children Older than 5 Years). Global Initiative for Asthma [Internet]. 2015 [updated 2009 Dec; cited 2017 Feb 12]. Available from: http://ginasthma.org/wp-content/uploads/2016/01/GINA_Pocket_2015.pdf.
Sarpong EM, Miller GE. Changes in Children's Use and Expenditures for Asthma Medications, United States, 1997-1998 to 2007-2008. Agency for Healthcare Research and Quality [Internet]. 2011 [updated 2011 Dec; cited 2017 Feb 12]. Available from: https://meps.ahrq.gov/data_files/publications/st341/stat341.shtml
Soni A. Top five most costly conditions among children, ages 0–17, 2012: estimates for the U.S. civilian noninstitutionalized population [Internet]. Statistical Brief. 2015;472 [updated 2016 Apr 26; cited 2017 Feb 12]. Available from: http://meps.ahrq.gov/mepsweb/data_files/publications/st472/stat472.pdf
Manmino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for asthma - united states 1980-1999. MMWR Surveill Summ. 2002;51(SS01):1-13.
Washington DC. Respiratory diseases. Healthy People. 2010;2: 20-2.
Wenzel S. Severe asthma: From characteristics to phenotypes to endotypes. Clin Exp Allergy. 2012 May;42(5):650-8. doi: 10.1111/j.1365-2222.2011.03929.x.
##submission.downloads##
Опубліковано
Номер
Розділ
Ліцензія
Авторське право (c) 2017 O. Koloskova
Ця робота ліцензується відповідно до Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Часопис користується «Типовим шаблоном положення про авторські права».