ПАТОГЕНЕЗ ПОРУШЕНЬ ПРО- ТА АНТИКОАГУЛЯНТНИХ ВЗАЄМОВІДНОСИН ЗА УМОВ ГОСТРОГО ПОРУШЕННЯ МОЗКОВОГО КРОВООБІГУ
DOI:
https://doi.org/10.24061/1727-4338.XXI.1.79.2022.16Ключові слова:
гострі порушення мозкового кровообігу, гемокоагуляція, патогенезАнотація
Мета роботи – проаналізувати сучасні погляди на патогенез дисбалансу у системі
гемокоагуляції при гострих порушеннях церебрального кровообігу та роль окремих
факторів зсіданні крові церебрального походження у механізмах ішемічно-
реперфузійного ушкодження мозку.
Висновок. Аналіз сучасних поглядів на стан гемокоагуляції при гострих розладах
мозкового кровообігу засвідчує наявність як системних, так і церебральних
порушень факторів гемостазу та їх взаємозалежність у механізмах ушкодження
мозку.
Посилання
Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ
Res. 2017;120(3):439-48. doi: 10.1161/circresaha.116.308413
Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang
AR, Cheng S, et al. Heart Disease and Stroke Statistics-2018
Update: A Report From the American Heart Association.
Circulation [Internet]. 2018[cited 2022 Apr 11];137(12): e67-e492.
Available from: https://www.ahajournals.org/doi/pdf/10.1161/
CIR.0000000000000558 doi: 10.1161/cir.0000000000000558
Bahnasy WS, Ragab OAA, Elhassanien ME. Stroke onset to
needle delay: Where these golden hours are lost? An Egyptian
center experience. eNeurologicalSci [Internet]. 2019[cited 2022
Apr 23];14:68-71. Available from: https://www.ncbi.nlm.nih.
gov/pmc/articles/PMC6330381/pdf/main.pdf doi: 10.1016/j.
ensci.2019.01.003
Meschia JF, Brott T. Ischaemic stroke. Eur J Neurol.
;25(1):35-40. doi: 10.1111/ene.13409
Waldman A, Rawal AR. Stroke Center Certifi cation [Internet].
Treasure Island (FL): StatPearls Publishing; 2019[cited 2022
Apr 24]. Available from: https://www.ncbi.nlm.nih.gov/books/
NBK535392/
Mischenko TS. Analiz epidemiolohii tserebrovaskuliarnykh
khvorob v Ukraini [Analysis of the epidemiology of cerebrovascular
diseases in Ukraine]. Sudynni zakhvoriuvannia holovnoho mozku.
;3:2-9. (in Ukrainian)
Zozulia YuP, Mischenko TS. Problemy sudynno- tserebral’noi patolohii
ta shliakhy yikh vyrishennia [Problems of vascular and cerebral
pathology and ways to solve them]. Zhurnal Hatsional’noi Akademii
medychnykh nauk Ukrainy. 2011;17(1):19-25. (in Ukrainian)
Polishchuk ME, Shchehlov DV, Goncharuk OM, Mamonova MYu,
Konotopchyk SV. Suchasnyi stan ta perspektyvy likuvannia insul’tiv
v Ukraini [Current status and prospects stroke treatment in Ukraine].
Ендоваскулярна нейрорентгенохірургія. 2017;4:14-22. doi:
26683/2304-9359-2017-4(22)-14-22 (in Ukrainian)
Goldman S, Prior SM, Bembenek JP, Niewada M, Broniatowska
E, Członkowska A, et al. Activation of blood coagulation and
thrombin generation in acute ischemic stroke treated with rtPA.
J Thromb Thrombolysis. 2017;44(3):362-70. doi: 10.1007/
s11239-017-1544-7
Bembenek JP, Niewada M, Siudut J, Plens K, Członkowska A,
Undas A. Fibrin clot characteristics in acute ischaemic stroke
patients treated with thrombolysis: the impact on clinical outcome.
Thromb Haemost. 2017;117(7):1440-7. doi: 10.1160/th16-12-0954
Thibodeau A, Geng X, Previch LE, Ding Y. Pyruvate dehydrogenase
complex in cerebral ischemia- reperfusion injury. Brain Circ.
;2(2):61-6. doi: 10.4103/2394-8108.186256
Cai L, Thibodeau A, Peng C, Ji X, Rastogi R, Xin R, et al.
Combination therapy of normobaric oxygen with hypothermia
or ethanol modulates pyruvate dehydrogenase complex
in thromboembolic cerebral ischemia. J Neurosci Res.
;94(8):749-58. doi: 10.1002/jnr.23740
Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam
HF. Pathogenic mechanisms following ischemic stroke. Neurol
Sci. 2017;38(7):1167-86. doi: 10.1007/s10072-017-2938-1
Chen J, Li Z, Hatcher JT, Chen QH, Chen L, Wurster RD, et al.
Deletion of TRPC6 Attenuates NMDA Receptor- Mediated Ca2+
Entry and Ca2+-Induced Neurotoxicity Following Cerebral
Ischemia and Oxygen- Glucose Deprivation. Front Neurosci
[Internet]. 2017[cited 2022 Apr 19];11:138. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368256/pdf/
fnins-11-00138.pdf doi: 10.3389/fnins.2017.00138
Boychuk TM, Tkachuk SS, Nika OM. Modyfi kuiuchyi vplyv
tsukrovoho diabetu na reaktsiiu r53-zalezhnykh proapoptychnykh
mekhanizmiv hipokampa schuriv u dynamitsi ishemichno-
reperfuziinoho poshkodzhennia holovnoho mozku [The modifying
eff ect of diabetes mellitus on the reaction of р53-dependent
proapoptotic mechanisms of hippocampus of rats in dynamic of
ischemic- reperfusion damage of brain]. Pathologia. 2016;3:9-13.
doi: 10.14739/2310-1237.2016.3.86935 (in Ukrainian)
Boychuk TM, Nika OM, Tkachuk SS. Spivvidnoshennia r53-pro-
ta Bcl-2-antyapoptychnoi aktyvnosti v hipokampi schuriv z
ishemiieiu- reperfuziieiu holovnoho mozku ta eksperymental’nym
diabetom [The ratio of p53-proapoptotic and Bcl-2 antiapoptotic
activity in the hippocampus of rats with brain ischemia-
reperfusion and experimental diabetes]. Fiziologichnyi Zhurnal.
;62(6):25-33. doi: 10.15407/fz62.06.025 (in Ukrainian)
Supanc V, Biloglav Z, Kes VB, Demarin V. Role of cell
adhesion molecules in acute ischemic stroke. Ann Saudi Med.
;31(4):365-70. doi: 10.4103/0256-4947.83217
Sokhor NR, Shkrobot SI, Yasnii OR. Mediatory zapalennia
u hostromu pidtypi riznykh pidtypiv ishemichnoho insul’tu
[Infl ammatory mediators during the acute period of diff erent
subtypes of ischemic stroke]. Bukovinian Medical Herald.
;17(1):126-9. doi: 10.24061/2413-0737.XVII.1.65.2013.31
(in Ukrainian)
Iwasa K, Yamamoto S, Yagishita S, Maruyama K, Yoshikawa
K. Excitotoxicity- induced prostaglandin D2 production induces
sustained microglial activation and delayed neuronal death. J Lipid
Res. 2017;58(4):649-55. doi: 10.1194/jlr.m070532
Fan H, Wu PF, Zhang L, Hu ZL, Wang W, Guan XL, et al.
Methionine sulfoxide reductase. A negatively controls microglia-
mediated neuroinfl ammation via inhibiting ROS/MAPKs/
NF-kappaB signaling pathways through a catalytic antioxidant
function. Antioxid Redox Signal. 2015;22(10):832-47. doi:
1089/ars.2014.6022
Lakhan SE, Kirchgessner A, Tepper D, Leonard A. Matrix
Metalloproteinases and Blood- Brain Barrier Disruption in Acute
Ischemic Stroke. Front Neurol [Internet]. 2013[cited 2022 Apr
;4:32. Available from: https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC3615191/pdf/fneur-04-00032.pdf doi: 10.3389/
fneur.2013.00032
Yilmaz AB, Gokhan S, Sener A, Erel O. Analysis of Neutrophil/
Lymphocyte ratio and Thiol/Disulfi de homeostasis parameters
in patients admitted to the emergency department with ischemic
stroke. Pak J Med Sci. 2018;34(6):1418-23. doi: 10.12669/
pjms.346.16242
Hermann DM, Kleinschnitz C, Gunzer M. Role of
polymorphonuclear neutrophils in the reperfused ischemic
brain: insights from cell-type-specifi c immunodepletion and
fl uorescence microscopy studies. Ther Adv Neurol Disord
[Internet]. 2018[cited 2022 Apr 19];11:1756286418798607.
Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC6144496/pdf/10.1177_1756286418798607.pdf doi:
1177/1756286418798607
Siniscalchi A, Gallelli L, Malferrari G, Pirritano D, Serra R,
Santangelo E, et al. Cerebral stroke injury: the role of cytokines
and brain infl ammation. J Basic Clin Physiol Pharmacol.
;25(2):131-7. doi: 10.1515/jbcpp-2013-0121
Sfredel MD, Burada E, Cătălin B, Dinescu V, Târtea G, Iancău M,
et al. Blood Coagulation Following an Acute Ischemic Stroke. Curr
Health Sci J. 2018;44(2):118-21. doi: 10.12865/chsj.44.02.04
Stoll G, Kleinschnitz C, Nieswandt B. Molecular mechanisms
of thrombus formation in ischemic stroke: novel insights and
targets for treatment. Blood. 2008;112(9):3555-62. doi: 10.1182/
blood-2008-04-144758
Sachs UJH, Nieswandt B. In vivo thrombus formation in
murine models. Circ Res. 2007;100(7):979-91. doi: 10.1161/01.
res.0000261936.85776.5f
Wolberg AS, Aleman MM, Leiderman K, Machlus KR.
Procoagulant activity in hemostasis and thrombosis: Virchow’s
triad revisited. Anesth Analg. 2012;114(2):275-85. doi: 10.1213/
ane.0b013e31823a088c
Periayah MH, Halim AS, Saad AZM. Mechanism Action of
Platelets and Crucial Blood Coagulation Pathways in Hemostasis.
Int J Hematol Oncol Stem Cell Res. 2017;11(4):319-27.
Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt
B, Stoll G. Targeting platlets in acute experimental stroke:
impact of glycoprotein Ib, VI, IIb/IIa blockade on infarct size,
functional outcome, and intracranial bleeding. Circulation.
;115(17):2323-30. doi: 10.1161/circulationaha.107.691279
Mojzisch A, Brehm MA. The Manifold Cellular Functions of
von Willebrand Factor. Cells [Internet]. 2021[cited 2022 Apr
;10(9):2351. https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC8466076/pdf/cells-10-02351.pdf doi: 10.3390/cells10092351
Ansari J, Gavins FNE. Biomedicines. Neutrophils and Platelets:
Immune Soldiers Fighting Together in Stroke Pathophysiology.
Biomedicines [Internet]. 2021[cited 2022 Apr 24];9(12):1945.
Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC8698717/pdf/biomedicines-09-01945.pdf doi: 10.3390/
biomedicines9121945
Xu RG, Gauer JS, Baker SR, Slater A, Martin EM, McPherson
HR, et al. GPVI (Glycoprotein VI) Interaction With Fibrinogen Is
Mediated by Avidity and the Fibrinogen αC-Region. Arterioscler
Thromb Vasc Biol. 2021;41(3):1092-1104. doi: 10.1161/
atvbaha.120.315030
Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu
H, et al. Clustering of glycoprotein VI (GPVI) dimers upon adhesion
to collagen as a mechanism to regulate GPVI signaling in platelets. J
Thromb Haemost. 2017;15(3):549-64. doi: 10.1111/jth.13613
Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, Ajzenberg
N, et al. Platelet glycoprotein VI dimerization, an active process
inducing receptor competence, is an indicator of platelet reactivity.
Arterioscler Thromb Vasc Biol. 2012;32(3):778-85. doi: 10.1161/
atvbaha.111.241067
Navarro S, Stegner D, Nieswandt B, Heemskerk JWM, Kuijpers
MJE. Temporal Roles of Platelet and Coagulation Pathways in
Collagen- and Tissue Factor- Induced Thrombus Formation. Int J
Mol Sci. 2022;23:358. 10.3390/ijms23010358
Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer H-U, Burfeind
P, et al. Targeting coagulation factor XII provides protection from
pathological thrombosis in cerebral ischemia without interfering
with hemostasis. J Exp Med. 2006;203(3):513-8 doi: 10.1084/
jem.20052458
Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A,
Seligsohn U. Patients with severe factor XI defi ciency have
a reduced incidence of deep-vein thrombosis. Thromb Haemost.
;105(2):269-73. doi: 10.1160/th10-05-0307
Krenzlin H, Lorenz V, Danckwardt S, Kempski O, Alessandri
B. The Importance of Thrombin in Cerebral Injury and Disease. Int
J Mol Sci [Internet]. 2016[cited 2022 Apr 12];17(1): E84. Available
from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730327/
pdf/ijms-17-00084.pdf doi: 10.3390/ijms17010084
Sokolova E, Reiser G. Prothrombin/thrombin and the thrombin
receptors PAR-1 and PAR-4 in the brain: Localization, expression
and participation in neurodegenerative diseases. Thromb Haemost.
;100(4):576-81. doi: 10.1160/TH08-03-0131
Bushi D, Stein ES, Golderman V, Feingold E, Gera O, Chapman J,
et al. A Linear Temporal Increase in Thrombin Activity and Loss
of Its Receptor in Mouse Brain following Ischemic Stroke. Front
Neurol [Internet]. 2017[cited 2022 Apr 12];8:138. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385331/pdf/
fneur-08-00138.pdf doi: 10.3389/fneur.2017.00138
Bushi D, Ben Shimon M, Shavit Stein E, Chapman J, Maggio N,
Tanne D. Increased thrombin activity following reperfusion after
ischemic stroke alters synaptic transmission in the hippocampus. J
Neurochem. 2015;135(6):1140-8. doi: 10.1111/jnc.13372
Striggow F, Riek M, Breder J, Henrich- Noack P, Reymann KG,
Reiser G. The protease thrombin is an endogenous mediator
of hippocampal neuroprotection against ischemia at low
concentrations but causes degeneration at high concentrations.
Proc Natl Acad Sci USA. 2000;97(5):2264-9. doi: 10.1073/
pnas.040552897
Bao X, Hua Y, Keep RF, Xi G. Thrombin- induced tolerance
against oxygen- glucose deprivation in astrocytes: role of protease-
activated receptor-1. Cond Med. 2018;1(2):57-63.
Mirante O, Price M, Puentes W, Castillo X, Benakis C, Thevenet
J, et al. Endogenous protease nexin-1 protects against cerebral
ischemia. Int J Mol Sci. 2013;14(8):16719-31. doi: 10.3390/
ijms140816719
Krämer TJ, Sakas W, Jussen D, Krenzlin H, Kempski O, Alessandri
B. Thrombin contributes to the injury development and neurological
defi cit after acute subdural hemorrhage in rats only in collaboration
with additional blood- derived factors. BMC Neurosci [Internet].
[cited 2022 Apr 21];19(1):81. Available from: https://www.
ncbi.nlm.nih.gov/pmc/articles/PMC6307215/pdf/12868_2018_
Article_481.pdf doi: 10.1186/s12868-018-0481-5
Wu X, Zhang W, Li JY, Chai BX, Peng J, Wang H, et al. Induction
of apoptosis by thrombin in the cultured neurons of dorsal motor
nucleus of the vagus. Neurogastroenterol Motil. 2011;23(3):279-85.
doi: 10.1111/j.1365-2982.2010.01641.x
Pleşeru AM, Mihailă RG. The role of thrombin in central nervous
system activity and stroke. Clujul Med. 2018;91(4):368-71. doi:
15386/cjmed-973
Chen B. Thrombin in Ischemic Stroke Targeting. In: Lapchak PA,
Zhang JH, editors. Translational Stroke Research: From Target
Selection to Clinical Trials. New York: Springer; 2012, р. 189-204.
Brailoiu E, Shipsky MM, Yan G, Abood ME, Brailoiu GC.
Mechanisms of modulation of brain microvascular endothelial
cells function by thrombin. Brain Res. 2017;1657:167-75. doi:
1016/j.brainres.2016.12.011
Stein ES, Itsekson- Hayosh Z, Aronovich A, Reisner Y, Bushi D,
Pick CG, et al. Thrombin induces ischemic LTP (iLTP): implications
for synaptic plasticity in the acute phase of ischemic stroke. Sci
Rep [Internet]. 2015[cited 2022 Apr 21];5:7912. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300504/pdf/
srep07912.pdf doi: 10.1038/srep07912
Olson NC, Butenas S, Lange LA, Lange EM, Cushman M,
Jenny NS, et al. Coagulation factor XII genetic variation, ex
vivo thrombin generation, and stroke risk in the elderly: results
from the Cardiovascular Health Study. J Thromb Haemost.
;13(10):1867-77. doi: 10.1111/jth.13111
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