КЛІТИННА ЗАГИБЕЛЬ: СУЧАСНИЙ ПОГЛЯД НА АПОПТОЗ ТА АУТОФАГІЮ
DOI:
https://doi.org/10.24061/1727-4338.XXII.2.84.2023.11Ключові слова:
клітинна загибель, апоптоз, автофагіяАнотація
Мета роботи – здійснити аналіз даних літератури стосовно сучасного стану
досліджень клітинної загибелі, взаємозв’язку сигнальних шляхів апоптозу й
аутофагії в умовах різних патологій, а також ключових посередників обох процесів.
Висновки. Дані літератури засвідчують про наявність чіткого взаємозв’язку
сигнальних шляхів апоптозу й аутофагії в умовах різних патологічних процесів,
який здійснюється через ключові посередники, зокрема кальцій (Ca2+), ліпідні
рафти, ERLIN, PINK1 тощо. Клітинна загибель є перспективною терапевтичною
мішенню для лікування захворювань у людини.
Посилання
Galluzzi L, Blomgren K, Kroemer G. Mitochondrial membrane
permeabilization in neuronal injury. Nat Rev Neurosci.
;10(7):481-94. doi: 10.1038/nrn2665
Kers J, Leemans JC, Linkermann A. An overview of pathways
of regulated necrosis in acute kidney injury. Semin Nephrol.
;36(3):139-52. doi: 10.1016/j.semnephrol.2016.03.002
Fuchs Y, Steller H. Programmed cell death in animal development and
disease. Cell. 2011;147(4):742-58. doi: 10.1016/j.cell.2011.10.033
Delbridge ARD, Grabow S, Strasser A, Vaux DL. Thirty years
of BCL-2: translating cell death discoveries into novel cancer
therapies. Nat Rev Cancer. 2016;16(2):99-109. doi: 10.1038/
nrc.2015.17
Dillon CP, Green DR. Molecular cell biology of apoptosis and
necroptosis in cancer. Adv Exp Med Biol. 2016;930:1-23. doi:
1007/978-3-319-39406-0_1
Linkermann A, Stockwell BR, Krautwald S, Anders HJ. Regulated
cell death and inflammation: an auto-amplification loop causes
organ failure. Nat Rev Immunol. 2014;14(11):759-67. doi:
1038/nri3743
Yatim N, Cullen S, Albert ML. Dying cells actively regulate
adaptive immune responses. Nat Rev Immunol. 2017;17(4):262-75.
doi: 10.1038/nri.2017.9
Dudek AM, Garg AD, Krysko DV, De Ruysscher D, Agostinis
P. Inducers of immunogenic cancer cell death. Cytokine Growth
Factor Rev. 2013;24(4):319-33. doi: 10.1016/j.cytogfr.2013.01.005
Inoue H, Tani K. Multimodal immunogenic cancer cell death as
a consequence of anticancer cytotoxic treatments. Cell Death
Differ. 2014;21(1):39-49. doi: 10.1038/cdd.2013.84
Conrad M, Angeli JPF, Vandenabeele P, Stockwel BR. Regulated
necrosis: disease relevance and therapeutic opportunities. Nat Rev
Drug Discov. 2016;15(5):348-66. doi: 10.1038/nrd.2015.6
Weinlich R, Oberst A, Beere HM, Green DR. Necroptosis in
development, inflammation and disease. Nat Rev Mol Cell Biol.
;18(2):127-36. doi: 10.1038/nrm.2016.149
Galluzzi L, Kepp O, Chan FKM, Kroemer G. Necroptosis:
mechanisms and relevance to disease. Annu Rev Pathol.
;12:103-30. doi: 10.1146/annurev- pathol-052016-100247
Maskarinec SF, McKelvy M, Boyle K, Hotchkiss H, Duarte ME,
Addison B, et al. Neutrophil functional heterogeneity is a fixed
phenotype and is associated with distinct gene expression profiles.
J Leukoc Biol. 2022;112(6):1485-95. doi: 10.1002/jlb.4a0322-164r
Hartel JC, Merz N, Grösch S. How sphingolipids affect T cells in the
resolution of inflammation. Front Pharmacol [Internet]. 2022[cited
Aug 15];13:1002915. Available from: https://www.ncbi.nlm.
nih.gov/pmc/articles/PMC9513432/pdf/fphar-13-1002915.pdf doi:
3389/fphar.2022.1002915
Garg AD, Martin SM, Golab J, Agostinis P. Danger signalling
during cancer cell death: origins, plasticity and regulation. Cell
Death Differ. 2014;21(1):26-38. doi: 10.1038/cdd.2013.48
Vandenabeele P, Vandecasteele K, Bachert C, Krysko O,
Krysko D. Immunogenic apoptotic cell death and anticancer
immunity. Adv Exp Med Biol [Internet]. 2016[cited
Aug 17];930:133-49. Available from: https://link.
springer.com/chapter/10.1007/978-3-319-39406-0_6 doi:
1007/978-3-319-39406-0_6
Hernandez C, Huebener P, Schwabe RF. Damage- associated
molecular patterns in cancer: a double- edged sword. Oncogene.
;35(46):5931-41. doi: 10.1038/onc.2016.104
Soares M, Teixeira L, Moita LF. Disease tolerance and immunity
in host protection against infection. Nat Rev Immunol.
;17(2):83-96. doi: 10.1038/nri.2016.136
Gabusi E, Lenzi E, Manferdini C, Dolzani P, Columbaro M, Saleh Y, et
al. Autophagy Is a Crucial Path in Chondrogenesis of Adipose- Derived
Mesenchymal Stromal Cells Laden in Hydrogel. Gels [Internet].
[cited 2023 Aug 15];24;8(12):766. Available from: https://www.
mdpi.com/2310-2861/8/12/766 doi: 10.3390/gels8120766
Mu W, Rezek V, Martin H, Carrillo MA, Tomer S, Hamid P, et al.
Autophagy inducer rapamycin treatment reduces IFN-I-mediated
Inflammation and improves anti- HIV-1 T cell response in vivo. JCI
Insight [Internet]. 2022[cited 2023 Aug 17];7(22): e159136. Available
from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746825/
pdf/jciinsight-7-159136.pdf doi: 10.1172/jci.insight.159136
Schweichel JU, Merker HJ. The morphology of various types of
cell death in prenatal tissues. Teratology. 1973;7(3):253-66. doi:
1002/tera.1420070306
Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L,
et al. Cell death modalities: classification and pathophysiological
implications. Cell Death Differ. 2007;14(7):1237-43. doi: 10.1038/
sj.cdd.4402148
Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D,
Vandenabeele P, et al. Classification of cell death: recommendations
of the Nomenclature Committee on Cell Death. Cell Death Differ.
;12(Suppl 2):1463-67. doi: 10.1038/sj.cdd.4401724
Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES,
Baehrecke EH, et al. Classification of cell death: recommendations
of the Nomenclature Committee on Cell Death 2009. Cell Death
Differ. 2009;16(1):3-11. doi: 10.1038/cdd.2008.150
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW,
Baehrecke EH, et al. Guidelines for the use and interpretation of
assays for monitoring cell death in higher eukaryotes. Cell Death
Differ. 2009;16(8):1093-107. doi: 10.1038/cdd.2009.44
Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH,
Blagosklonny MV, et al. Molecular definitions of cell death
subroutines: recommendations of the Nomenclature Committee
on Cell Death 2012. Cell Death Differ. 2012;19(1):107-20. doi:
1038/cdd.2011.96
Galluzzi L, Pedro JMBS, Vitale I, Aaronson SA, Abrams JM,
Adam D, et al. Essential versus accessory aspects of cell death:
recommendations of the NCCD 2015. Cell Death Differ.
;22(1):58-73. doi: 10.1038/cdd.2014.137
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis
P, et al. Molecular mechanisms of cell death: recommendations
of the Nomenclature Committee on Cell Death 2018. Cell Death
Differ. 2018;25(3):486-541. doi: 10.1038/s41418-017-0012-4
Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis
N. Crosstalk between apoptosis, necrosis and autophagy.
Biochim Biophys Acta. 2013;1833(12):3448-59. doi: 10.1016/j.
bbamcr.2013.06.001
Redondo M, Fùnez R, Esteban F. Apoptosis in the Development and
Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin.
In: Chen GG, Lai PBS, editors. Apoptosis in Carcinogenesis and
Chemotherapy. Dordrecht: Springer; 2009, p. 237-49.
Chaudhry GES, Akim AM, Sung YY, Sifzizul TMT. Cancer and
apoptosis: The apoptotic activity of plant and marine natural products
and their potential as targeted cancer therapeutics. Front Pharmacol
[Internet]. 2022[cited 2023 Aug 15];13:842376. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9399632/pdf/
fphar-13-842376.pdf doi: 10.3389/fphar.2022.842376
Sheshachalam A, Srivastava N, Mitchell T, Lacy P, Eitzen
G. Granule Protein Processing and Regulated Secretion in
Neutrophils. Front Immunol [Internet]. 2014[cited 2023 Aug
;5:448. Available from: https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC4168738/pdf/fimmu-05-00448.pdf doi: 10.3389/
fimmu.2014.00448
Trapani J. Granzymes: a family of lymphocyte granule serine
proteases. Genome Biol [Internet]. 2001[cited 2023 Aug
;2(12); reviews3014.1-reviews3014.7. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138995/
pdf/gb-2001-2-12-reviews3014.pdf doi: 10.1186/
gb-2001-2-12-reviews3014
Gudipaty SA, Conner CM, Rosenblatt J, Montell D. Unconventional
Ways to Live and Die: Cell Death and Survival in Development,
Homeostasis, and Disease. Annu Rev Cell Dev Biol.
;34:311-32. doi: 10.1146/annurev- cellbio-100616-060748
Galluzzi L, Pedro JMBS, Blomgren K, Kroemer G. Autophagy
in acute brain injury. Nat Rev Neurosci. 2016;17(8):467-84. doi:
1038/nrn.2016.51
Anding A, Baehrecke E. Autophagy in Cell Life and Cell
Death. Curr Top Dev Biol. 2015;114:67-91. doi: 10.1016/
bs.ctdb.2015.07.012
Xu T, Nicolson S, Denton D, Kumar S. Distinct requirements of
Autophagy- related genes in programmed cell death. Cell Death
Differ. 2015;22(11):1792-802. doi: 10.1038/cdd.2015.28
Galluzzi L, Pedro JMBS, Levine B, Green DR, Kroemer
G. Pharmacological modulation of autophagy: therapeutic
potential and persisting obstacles. Nat Rev Drug Discov.
;16(7):487-511. doi: 10.1038/nrd.2017.22
Gatica D, Chiong M, Lavandero S, Klionsky DJ. Molecular
mechanisms of autophagy in the cardiovascular system. Circ Res.
;116(3):456-67. doi: 10.1161/circresaha.114.303788
Kouroumalis E, Tsomidis I, Voumvouraki A. Pathogenesis of
Hepatocellular Carcinoma: The Interplay of Apoptosis and
Autophagy. Biomedicines [Internet]. 2023[cited 2023 Aug
;11(4):1166. Available from: https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC10135776/pdf/biomedicines-11-01166.pdf doi:
3390/biomedicines11041166
Wang B, Wang Y, Zhang J, Hu C, Jiang J, Li Y, et al. ROS-induced
lipid peroxidation modulates cell death outcome: mechanisms
behind apoptosis, autophagy, and ferroptosis. Arch Toxicol.
;97(6):1439-51. doi: 10.1007/s00204-023-03476-6
Gao L, Loveless J, Shay C, Teng Y. Targeting ROS-Mediated
Crosstalk Between Autophagy and Apoptosis in Cancer. Adv Exp
Med Biol. 2020;1260:1-12. doi: 10.1007/978-3-030-42667-5_1
Gao G, Chen W, Yan M, Liu J, Luo H, Wang C, et al. Rapamycin
regulates the balance between cardiomyocyte apoptosis and
autophagy in chronic heart failure by inhibiting mTOR signaling.
Int J Mol Med. 2020;45(1):195-209. doi: 10.3892/ijmm.2019.4407
Dong Y, Chen H, Gao J, Liu Y, Li J, Wang J. Molecular machinery
and interplay of apoptosis and autophagy in coronary heart
disease. J Mol Cell Cardiol. 2019;136:27-41. doi: 10.1016/j.
yjmcc.2019.09.001
Liu J, Liu W, Yang H. Balancing Apoptosis and Autophagy
for Parkinson’s Disease Therapy: Targeting BCL-2.
ACS Chem Neurosci. 2019;10(2):792-802. doi: 10.1021/
acschemneuro.8b00356
Kim D, Song J, Jin EJ. BNIP3-Dependent Mitophagy via PGC1α
Promotes Cartilage Degradation. Cells [Internet]. 2021[cited
Aug 15];10(7):1839. Available from: https://www.ncbi.nlm.
nih.gov/pmc/articles/PMC8304751/pdf/cells-10-01839.pdf doi:
3390/cells10071839
Celia AI, Colafrancesco S, Barbati C, Alessandri C, Conti
F. Autophagy in Rheumatic Diseases: Role in the Pathogenesis and
Therapeutic Approaches. Cells [Internet]. 2022[cited 2023 Aug
;11(8):1359. Available from: https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC9025357/pdf/cells-11-01359.pdf doi: 10.3390/
cells11081359
Wang X, Wang L, Xiang W. Mechanisms of ovarian aging in
women: a review. J Ovarian Res [Internet]. 2023[cited 2023 Aug
;16(1):67. Available from: https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC10080932/pdf/13048_2023_Article_1151.pdf doi:
1186/s13048-023-01151-z
Sukumaran P, Da Conceicao VТ, Sun Y, Ahamad N, Saraiva LК,
Selvaraj S, et al. Calcium Signaling Regulates Autophagy and
Apoptosis. Cells [Internet]. 2021[cited 2023 Aug 15];10(8):2125.
Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC8394685/pdf/cells-10-02125.pdf doi: 10.3390/cells10082125
Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun
U, et al. Adaptive Lipid Packing and Bioactivity in Membrane
Domains. PLoS One [Internet]. 2015[cited 2023 Aug 19];10(4):
e0123930. Available from: https://www.ncbi.nlm.nih.gov/pmc/
articles/PMC4408024/pdf/pone.0123930.pdf doi: 10.1371/journal.
pone.0123930
Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane
organization: Composition, regulation and roles of lipid rafts. Nat
Rev Mol Cell Biol. 2017;18(6):361-74. doi: 10.1038/nrm.2017.16
Garofalo T, Manganelli V, Grasso M, Mattei V, Ferri A, Misasi
R, et al. Role of mitochondrial raft-like microdomains in the
regulation of cell apoptosis. Apoptosis. 2015;20(5):621-34. doi:
1007/s10495-015-1100-x
Manganelli V, Matarrese P, Antonioli M, Gambardella L,
Vescovo T, Gretzmeier C, et al. Raft-like lipid microdomains
drive autophagy initiation via AMBRA1-ERLIN1 molecular
association within MAMs. Autophagy. 2021;17(9):2528-48. doi:
1080/15548627.2020.1834207
Manganelli V, Longo A, Mattei V, Recalchi S, Riitano G,
Caissutti D, et al. Role of ERLINs in the Control of Cell Fate
through Lipid Rafts. Cells [Internet]. 2021[cited 2023 Aug
;10(9):2408. Available from: https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC8470593/pdf/cells-10-02408.pdf doi: 10.3390/
cells10092408
Brunelli F, Torosantucci L, Gelmetti V, Franzone D, Grünewald
A, Krüger R, et al. PINK1 Protects against StaurosporineInduced Apoptosis by Interacting with Beclin1 and Impairing Its
Pro- Apoptotic Cleavage. Cells [Internet]. 2022[cited 2023 Aug
;11(4):678. Available from: https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC8870463/pdf/cells-11-00678.pdf doi: 10.3390/
cells11040678
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