DOI: https://doi.org/10.24061/1727-4338.XIII.1.47.2014.47

ЕКСПЕРИМЕНТАЛЬНЕ МОДЕЛЮВАННЯ АТЕРОСКЛЕРОЗУ: ПЕРСПЕКТИВИ ТА ТРУДНОЩІ

S. G. Kotjuzhinskaya, A. I. Gozhenko

Анотація


У роботі розглянуті відомі на сьогодні моделі атеросклеротичного процесу в експериментальних тварин і на клітинних культурах. Авторами запропонована експериментальна модель атеросклерозу, в основу якої покладено блокування тучних клітин і гепарину, що дозволило пригнітити ліпопротеїнліпазну активність крові, і в значною мірою підвищити частоту та тяжкість розвитку атеросклерозу в щурів. Проаналізовано можливості та обмеження застосування лабораторних тварин для дослідження етіології та патогенезу атеросклерозу.

Ключові слова


атеросклероз; експериментальне моделювання

Повний текст:

PDF (Русский)

Посилання


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