ЕКСПЕРИМЕНТАЛЬНЕ МОДЕЛЮВАННЯ АТЕРОСКЛЕРОЗУ: ПЕРСПЕКТИВИ ТА ТРУДНОЩІ
DOI:
https://doi.org/10.24061/1727-4338.XIII.1.47.2014.47Ключові слова:
атеросклероз, експериментальне моделюванняАнотація
У роботі розглянуті відомі на сьогодні моделі атеросклеротичного процесу в експериментальних тварин і на клітинних культурах. Авторами запропонована експериментальна модель атеросклерозу, в основу якої покладено блокування тучних клітин і гепарину, що дозволило пригнітити ліпопротеїнліпазну активність крові, і в значною мірою підвищити частоту та тяжкість розвитку атеросклерозу в щурів. Проаналізовано можливості та обмеження застосування лабораторних тварин для дослідження етіології та патогенезу атеросклерозу.Посилання
Alekseeva RI. Kholesterin i ateroskleroz [Cholesterol and atherosclerosis]. Voprosy pitaniya. 1998;3:44-5. (in Russian).
Anesteadi VKh, Nagornev VA. O pato- i morfogeneze ateroskleroza (kliniko-eksperimental'nye aspekty) [On the patho-and morphogenesis of atherosclerosis (clinical and experimental aspects)]. Arkhiv patologii. 1984;46(3):10-3. (in Russian).
Bobryshev YuV, Karagodin VP, Kovalevskaya ZhI. Kletochnye mekhanizmy ateroskleroza: vrozhdennyy immunitet i vospalenie [Cellular mechanisms of atherosclerosis: innate immunity and inflammation]. Fundamental'nye nauki i praktika. 2010;1(4):140-48. (in Russian).
Klimov AN, Nagornev VA. Metodicheskie aspekty etiologii i patogeneza ateroskleroza [Methodological aspects of the etiology and pathogenesis of atherosclerosis]. Kardiologiya. 1993;2:5-10. (in Russian).
Nepomnyashchikh LM, Filyushina EE, Mishina SV. Morfologicheskaya kharakteristika miokarda krolikov pri eksperimental'nom ateroskleroze [Morphological characteristics of rabbit myocardium in experimental atherosclerosis]. Arkhiv patologii. 1976;5:42-7. (in Russian).
Nagornev VA. Metodologiya v izuchenii problemy ateroskleroza [Methodology in the study of the problem of atherosclerosis]. Meditsinskiy akademicheskiy zhurnal. 2005;5(3):121-33. (in Russian).
Nagornev VA, Bobryshev YuV. Strukturno-funktsional'naya kharakteristika poverkhnosti endoteliya aorty pri eksperimental'noy giperkholesterinemii [Structural and functional characteristics of the surface of the aortic endothelium in experimental hypercholesterolemia]. Arkhiv patologii. 1984;1:50-7. (in Russian).
Nepomnyashchikh LM. Morfogenez vazhneyshikh obshchepatologicheskikh protsessov v serdtse [Morphogenesis of the most important pathological processes in the heart]. Novosibirsk; 1991. 352 p. (in Russian).
Sokolova RI, Metelitsa VI. Izmeneniya aorty pri endogennoy giperkholesterinemii u krolikov (elektronno-mikroskopicheskoe issledovanie) [Aortic changes in endogenous hypercholesterolemia in rabbits (electron microscopic examination)]. Kardiologiya. 1971;6:72-5. (in Russian).
Nagornev VA, Bobryshev YuV, Popov AV, Vinogradov AG. Transport beta-lipoproteidov cherez endoteliy pri eksperimental'noy giperkholesterinemii (elektronno-radioavtograficheskoe issledovanie) [Beta-lipoprotein transport through the endothelium in experimental hypercholesterolemia (electron-radiographic study)]. Arkhiv patologii. 1982;44(1):10-7. (in Russian).
Ragino YuI, Chernyavskiy AM, Volkov AM. Faktory i mekhanizmy razvitiya koronarnogo ateroskleroza [Factors and mechanisms of coronary atherosclerosis]. Novosibirsk; 2011. 168 p. (in Russian).
Yuzhik EI, Lushnikova EL. Mediko-biologicheskie aspekty modelirovaniya ateroskleroticheskogo protsessa [Biomedical aspects of modeling the atherosclerotic process]. Fundamental'nye issledovaniya. 2012;10:176-83. (in Russian).
Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, et al. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007;27(4):878-85. doi: 10.1161/01.ATV.0000258790.35810.02.
Drolet MC, Roussel E, Deshaies Y, Couet J, Arsenault M. A high fat/ high carbohydrate diet induces aortic valve disease in C57BL/6J mice. J Am Coll Cardiol. 2006;47(4):850-5. doi: 10.1016/j.jacc.2005.09.049.
Abraham D, Handler C, Dashwood M, Coghlan G, еditors. Advances in vascular medicine. Springer-Verlag; 2010. 451 p.
Xiangdong L, Yuanwu L, Hua Z, Liming R, Qiuyan L, Ning L. Animal models for the atherosclerosis research: a review. Protein Cell. 2011;2(3):189-201. doi: 10.1007/s13238-011-1016-3.
Baranowski M. Biological role of liver X receptors. https://www.ncbi.nlm.nih.gov/pubmed/19258656">J Physiol Pharmacol. 2008;59(Suppl 7):31-55.
Dontas IA, Marinou KA, Iliopoulos D, Tsantila N, Agrogiannis G, Papalois A, et al. Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time or stress-effect. Lipids Health Dis. 2011;10:139. doi: 10.1186/1476-511X-10-139.
Luczak M, Formanowicz D, Pawliczak E, Wanic-Kossowska M, Wykretowicz A, Figlerowicz M. Chronic kidney disease-related atherosclerosis – proteomic studies of blood plasma. Proteome Sci. 2011;9:25. doi: 10.1186/1477-5956-9-25.
Clandinin MT, Yamashiro S. Dietary factors affecting the incidence of dietary fat-induced myocardial lesions. J Nutr. 1982;112(4):825-8. doi: 10.1093/jn/112.4.825.
Cole JE, Georgiou E, Monaco C. The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm. 2010;2010:393946. doi: 10.1155/2010/393946.
Verdeguer F, Castro C, Kubicek M, Pla D, Vila-Caballer M, Vinué A, et al. Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferation. Cardiovasc Res. 2007;76(2):340-50. doi: 10.1016/j.cardiores.2007.06.028.
Cox R. A. Cholesterol, triglycerides, and associated lipoproteins. In: Cox RA, Garcia-Palmieri MR. Clinical methods: the history, physical, and laboratory examinations. Boston: Butterworths; 1990, р. 153-160.
Pagler TA, Wang M, Mondal M, Murphy AJ, Westerterp M, Moore KJ, et al. Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased RAC1 signaling. Circ Res. 2011;108(2):194-200. doi: 10.1161/CIRCRESAHA.110.228619.
Zhu XY, Bentley MD, Chade AR, Ritman EL, Lerman A, Lerman LO. Early changes in coronary artery wall structure detected by microcomputed tomography in experimental hypercholesterolemia. Am J Physiol Heart Circ Physiol. 2007;293(3):H1997-2003. doi: 10.1152/ajpheart.00362.2007.
Salter AM, Hayashi R, al-Seeni M, Brown NF, Bruce J, Sorensen O, et al. Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density-lipoprotein receptor and on acyl-CoA: cholesterol acyltransferase activities in rat liver. Biochem J. 1991;276(Pt 3):825-32. doi: 10.1042/bj2760825.
Farnworth ER, Kramer JK, Corner AH, Thompson BK. The methionine and choline status of rat diets and their effects on nutrition and myocardial lesions. J Nutr. 1983;113(12):2442-54. doi: 10.1093/jn/113.12.2442
Fisher VW. Myocardial structural response following administration of a fatty diet to rats. Exp. Mol. Pathol. 1979;30(2):215-29. doi: https://doi.org/10.1016/0014-4800(79)90055-8" target="_blank">10.1016/0014-4800(79)90055-8.
Rekhter MD, Hicks GW, Brammer DW, Hallak H, Kindt E, Chen J, et al. Hypercholesterolemia causes mechanical weakening of rabbit atheroma: local collagen loss as a prerequisite of plaque rupture. Circ Res. 2000;86(1):101-8. doi: 10.1161/01.RES.86.1.101.
Ignatowski AC. In fluence of animal food on the organism of rabbits. Izv Imp. 1908;16:154-73.
Michell DL, Andrews KL, Woollard KJ, Chin-Dusting JP. Imaging leukocyte adhesion to the vascular endothelium at high intraluminal pressure. J Vis Exp. 2011;(54):3221. doi: 10.3791/3221
Imaizumi K. Diet and atherosclerosis in apolipoprotein E-deficient mice. Biosci Biotechnol Biochem. 2011;75(6):1023-35. doi: 10.1271/bbb.110059.
Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJ, et al. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation. 2004;110(22):3493-500. doi: 10.1161/01.CIR.0000148135.08582.97.
Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, et al. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic Zebra fish. J Clin Invest. 2011;121(12):4861-9. doi: 10.1172/JCI57755.
Shalhoub J, Falck-Hansen MA, Davies AH, Monaco C. Innate immunity and monocyte-macrophage activation in atherosclerosis. J Inflamm (Lond). 2011;8:9. doi: 10.1186/1476-9255-8-9
van Ditzhuijzen NS, van den Heuvel M, Sorop O, van Duin RW, Krabbendam-Peters I, van Haeren R, et al. Invasive coronary imaging in animal models of atherosclerosis. Neth Heart J. 2011 Oct;19(10):442-6. doi: 10.1007/s12471-011-0187-0.
Kunimoto M, Yamaguchi Y, Futagawa Y. Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia. Jap. J Pharmacol. 1986;42(2):261-67. doi: 10.1254/jjp.42.261.
Whitman SC, Rateri DL, Szilvassy SJ, Cornicelli JA, Daugherty A. Macrophage-specific expression of class A scavenger receptors in LDL receptor-/- mice decreases atherosclerosis and changes spleen morphology. J Lipid Res. 2002;43(8):1201-8.
Farris SD, Hu JH, Krishnan R, Emery I, Chu T, Du L, et al. Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins. J Biol Chem. 2011;286(25):22665-77. doi: 10.1074/jbc.M110.202135
Singh V, Tiwari RL, Dikshit M, Barthwal MK. Models to study atherosclerosis: a mechanistic insight. Curr Vasc Pharmacol. 2009;7(1):75-109. doi: 10.2174/157016109787354097.
Neyrinck AM, Van Hée VF, Bindels LB, De Backer F, Cani PD, Delzenne NM. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. Br J Nutr. 2013;109(5):802-9. doi: 10.1017/S0007114512002206.
Drobnik J, Dabrowski R, Szczepanowska A, Giernat L, Lorenc J. Response of aorta connective tissue matrix to injury caused by vasopressin-induced hypertension or hypercholesterolemia. J Physiol Pharmacol. 2000;51(3):521-33.
Rogers KA, Karnovsky MJ. Dietary fish oil enhances monocyte adhesion and fatty streak formation in the hypercholesterolemic rat. https://www.ncbi.nlm.nih.gov/pubmed/3400780">Am J Pathol. 1988;132(2):382-8.
Cullen P, Baetta R, Bellosta S, Bernini F, Chinetti G, Cignarella A, et al. Rupture of the atherosclerotic plaque: does a good animal model exist? Arterioscler Thromb Vasc Biol. 2003;23(4):535-42. doi: 10.1161/01.ATV.0000060200.73623.F8.
Santillo M, Migliaro A, Mondola P, Laezza C, Damiano S, Stingo S, et al. Dietary and hypothyroid hypercholesterolemia induces hepatic apolipoprotein E expression in the rat: direct role of cholesterol. FEBS Lett. 1999;463(1-2):83-6. doi: 10.1016/S0014-5793(99)01604-X
Santos MJ, Fonseca JE. Metabolic syndrome, inflammation and atherosclerosis – the role of adipokines in health and in systemic inflammatory rheumatic diseases. Acta Reumatol Port. 2009;34(4):590-8.
Ishii A, Viñuela F, Murayama Y, Yuki I, Nien YL, Yeh DT, et al. Swine model of carotid artery atherosclerosis: experimental induction by surgical partial ligation and dietary hypercholesterolemia. AJNR Am J Neuroradiol. 2006;27(9):1893-9.
Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathway. Physiol Rev. 2006;86(2):515-81. doi: 10.1152/physrev.00024.2005.
Hu Z, Zhang J, Guan A, Gong H, Yang M, Zhang G, et al. The granulocyte colony-stimulating factor promotes atherosclerosis in high-fat diet rabbits. Heart. 2011;97(3):A27. doi: 10.1136/heartjnl-2011-300867.77
Inoue Y, Toda T, Igawa T, Tani T, Kimura Y. The response of serum and hepatic lipids and the aortic wall to different levels of dietary cholesterol: a comparative study between hyperlipidemia-and-atherosclerosis-prone quail and commercially available quail. Tohoku J Exp Med. 1995;175(1):1-13. doi: 10.1620/tjem.175.1.
Vrins CL. From blood to gut: Direct secretion of cholesterol via transintestinal cholesterol efflux. https://www.ncbi.nlm.nih.gov/pubmed/21157971">World J Gastroenterol. 2010;16(47):5953-7. doi: 10.3748/wjg.v16.i47.5953.
Yasuda T, Ishida T, Rader DJ. Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis. Circ J. 2010;74(11):2263-70. doi: 10.1253/circj.CJ-10-0934.
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