INFLUENCE OF ALLELIC VARIANTS OF POLYMORPHIC GENES OF INTERLEUKINS, NITRIC OXIDE INDUCED SYNTHASE AND THEIR RECEPTORS IN THE COURSE OF HELICOBACTER-ASSOCIATED PEPTIC ULCER DISEASE IN CHILDREN

T. V. Sorokman, S. V. Sokolnyk, D. R. Andriychuk

Анотація


This paper presents the results of the analysis of the distribution of allelic polymorphism of interleukin-1beta gene, -8, receptor antagonist and interleukin-1-induced NO-synthase in children of Chernivtsy region suffering from stomach ulcer and duodenal ulcer and healthy. There was established that susceptibility to peptic ulcer disease associated with the presence of the following genotypes: IL-1β-511C/CR4/R4 IL-1Ra, IL-8-251A/T and C/C G954C in the promoter area of the gene induced NO-synthase. 


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DOI: https://doi.org/10.24061/1727-4338.XIII.4.50.2014.25

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