DOI: https://doi.org/10.24061/1727-4338.XIV.2.52.2015.54

МЕХАНІЗМИ СТАРІННЯ МОЗКУ ЯК ОСНОВА ВІКОВОЇ ДИСФУНКЦІЇ ЦЕНТРАЛЬНОЇ НЕРВОВОЇ СИСТЕМИ

S. S. Tkachuk, A. V. Tkachuk, V. F. Myslytskyi

Анотація


Проаналізовано сучасні погляди на механізми старіння мозку та їх взаємозв’язок із віковою дисфункцією центральної нервової системи.

Ключові слова


головний мозок; старіння; нейродегенеративні процеси

Повний текст:

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Посилання


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Пристатейна бібліографія ГОСТ


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5. Brain Aging: Models, Methods, and Mechanisms Frontiers in Neuroscience Ed. by David R. Riddle. : CRC Press, 2007.- 220 р.

 

6. Рейхардт Б.А. Динамика нарушений регуляторных систем нейронов мозга при возрастной амнезии у крыс / Б.А.Рейхардт, О.Г.Куликова, Н.С.Сапронов // Психофармакол. и биол. - 2001. - Т.1,№1. - С. 38-42.

 

7. Preservation of hippocampal neuron numbers in aged rhesus monkeys / J.I.Keuker, P.G.Luiten, E.Fuchs // Neurobiol. Aging.- 2003.- Vol.24,№1.- P.157-165.

 

8. Савченко М.А. Закономерности изменения физических качеств и психомоторных функций у женщин среднего и пожилого возраста / М.А.Савченко // Успехи геронтол. - 2008. - Т.21,№3. - С.427-430.

 

9. Rao R. The role of carotid stenosis in vascular cognitive impairmеnt / R.Rao //Eur. Neurol. - 2001. - Vol.46. - P. 30-34.

 

10. Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study / J.R.Romero, A.Beiser, S.Seshadri [et al.] // Stroke. - 2009. - Vol.40, №5. - Р.1590-1596.

 

11. Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats, ijected with Freunds adjuvant / P.Cano, D.P.Cardinali, F.Chacon [et al.] // BMC Physiology. - 2001. -Vol.1,№5. - Р.1149-1156.

 

12. Weinert B. T. Invited review: Theories of aging / B.T.Weinert, P.S.Timiras // J. Appl. Physiol. - 2003. - Vol. 95. - P. 1706-1716.

 

13. Finch C.E. Neurons, glia, and plasticity in normal brain aging / C.E.Finch // Успіхи геронтол.- 2002.- Т.10,№1.-С.35-39.

 

14. Hof P.R. The aging brain: morphomolecular senescence of cortical circuits/P.R.Hof, J.H.Morrison //Trends Neurosci.- 2004.- Vol. 27, №10.- P. 607-613.

 

15. LaFerla F.M. Calcium dyshomeostasis and intracellular signaling in Alzheimer disease /F.M.LaFerla //Nat. Rev. Neurosci.- 2002.- Vol.3,№11.- P.862-72.

 

16. Clodfelter G.V. Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons / G.V.Clodfelter // Eur. J. Pharmacol. -.2002. - Vol.447,№ 2-3. - Р. 189-200.

 

17. Yang Y. Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons / Y.Yang, D.G.Cook // Neurosci. - 2004. - Vol.124,№3. - Р. 501-505.

 

18. Prolla T.A. Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction / T.A.Prolla, M.P.Mattson // Trends Neurosci. - 2001. -Vol.24,№ 11. - Р.21-31.

 

19. Catterall W.A. Compendium of voltage-gated ion channels: calcium channels / W.A.Catterall // Pharmacol. Rev. - 2003. - Vol. 55,№. 4. - Р. 579.

 

20. Toescu E.C. Ca2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain aging / E.C.Toescu, A.Verkhratsky // J. Cell. Mol. Med. – 2004. - Vol.8,№2.- Р.181-190.

 

21. Cady C. Age-related differences in NMDA responses in cultured rat hippocampal neurons / C.Cady, M.S.Evans, G.J.Brewer // Brain Res.- 2001.- Vol.921,№ 19-21. - Р. 1-11.

 

22. Carlson N.G. RNA editing (Q/R site) and flop/flip splicing of AMPA receptor transcripts in young and old brains / N.G.Carlson // Neurobiol. Aging. - 2000. - Vol.21,№4. - Р.599-606.

 

23. Perez-Otano I. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors / I.Perez-Otano // J. Neurosci. - 2001. -Vol.21,№4. - Р. 1228-1237.

 

24. Clayton D.A. Deficits in the expression of the NR2B subunit in the hippocampus of aged Fisher 344 rats / D.A.Clayton, M.D.Browning // Neurobiol. Aging. - 2001.-Vol. 22,№1.- Р.165-168.

 

25. Tanaka H. The AMPAR subunit GluR2: still front and center-stage / H.Tanaka // Brain Res. - 2000. - Vol.886,№ 1-2. - Р. 190-207.

 

26. Anderton B.H. Aging of the brain // B.H. Anderton // Mech. Aging Dev. - 2002. - Vol.123,№7. - Р.811-817.

 

27. Chern Y. Regulation of adenylyl cyclase in the central nervous system / Y.Chern // Cell. Signal. - 2000.- Vol.12,№4. - Р. 195-204.

 

28. Wanaverbecq N. The plasma membrane calcium-ATPase as a major mechanism for intracellular calcium regulation in neurons from the rat superior cervical ganglion / N.Wanaverbecq // J. Physiol.- 2003.- Vol. 550, № 1. - Р. 83-101.

 

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30. Thinakaran G. Identification of the role of presenilins beyond Alzheimer’s disease / G.Thinakaran, A.T.Parent // Pharm. Res. - 2004.- Vol.50,№4.- Р. 411-418.

 

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